This textbook is prepared by a team of historians-researchers and teachers-methodologists, it characterizes the most important processes and events of the history of Siberia - the largest region occupying the space from the Ural Mountains to the Pacific Ocean - in close connection with the history of Russia. The political, economic, socio-cultural, and mental aspects of life in the regional community are traced from antiquity to the present day, and the contribution of Russian and other peoples of our country and outstanding personalities to the settlement and development of the expanses of North Asia is revealed. The manual is equipped with questions and tasks of different types, rich illustrated and cartographic material.The textbook, which is a module of the Innovative educational and methodological complex "History", provides the realization of the regional component of historical education. The materials of the manual can be included in the curriculum both as an elective course and for the study of the main course of Russia.